I am so excited for this conference. A stellar line-up of incredible researchers across disciplines, a beautiful location, and a great environment for younger scientists. And what a treat that I get to co-organize this with @levine-lab.bsky.social! www.grc.org/molecular-me...

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10/n We also removed self-conditioning in favor of the now “in-vogue” flow-based reasoning via recurrence - a concurrent development! And we cleaned and scaled the data with AtomWorks (github.com/RosettaCommo...), of course

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5/n Small-molecule binding deserves its own highlight. Here, the in silico improvements are an order of magnitude.

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4/n Consider protein–protein binding, where we have the most baselines. RFD4-Proteina defines a new Pareto frontier.

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1/n Crossover episode! We just released RFD4-Proteina, our latest protein design model - and the result of a year-long collaboration between the Baker Lab and NVIDIA GenAIR (the name says it all…). I hope you’ll agree - the results are astonishing. 🌐 Website: rfd4-proteina.org

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