Nate

nathanieldhess.bsky.social

21 August 2026 20:00

doi.org/10.1038/s415... from the JD Gross Lab doi.org/10.1073/pnas.2425261122 from the Barducci Group

Nate

nathanieldhess.bsky.social

21 August 2026 20:00

Finally, if you like our work, please also consider reading the work from other groups in this area: doi.org/10.1021/jacs.5c10918 and doi.org/10.1073/pnas.2408554121 from @lek-lab.bsky.social doi.org/10.1073/pnas.2321606121 from the Sosnick Group

Nate

nathanieldhess.bsky.social

21 August 2026 20:00

And what about applying these principles in cells? Tools are already being developed to ask these questions (see work from the Ebbinghaus lab doi.org/10.1103/dsw6-t4qf). For these applications it will be critical to resolve the impact of other molecules (e.g., RNA) on folding landscapes.

Nate

nathanieldhess.bsky.social

21 August 2026 20:00

It will be critical to use multiple modalities (computational and experimental) to dissect the interactions contributing to dually sequence-dependent folding on a case-by-case basis. These insights will enable engineering the sequence features of co-condensate IDPs to tune protein ensembles.

Nate

nathanieldhess.bsky.social

21 August 2026 19:59

In particular, combined theory + experimental work will be critical to map out more complex folding landscapes in condensates (i.e., tertiary structure). This can build on multiple experimental studies (e.g., studies that have looked at RRMs—see below).