New paper out now in Genome Medicine! 🎉 Which in vitro model best reflects human inflammatory disease? We profiled >150K PBMCs using #scRNAseq across 11 stimuli to map intra- & intercellular responses across 21 cell subsets. 🧵👇 doi.org/10.1186/s130... 🧪🧬🖥️ #SingleCell #AcademicSky

Show Post

To capture the underlying regulatory landscape, we inferred transcription factor activity driving response programs across cell types and stimuli. To resolve cell-cell crosstalk in mixed samples, we mapped intercellular signaling networks via ligand-receptor analysis. #Bioinformatics #Immunology

Show Post

We then aligned these in vitro profiles against clinical datasets across multiple inflammatory diseases (with a deep dive into SLE) to identify which models best capture patient biology. The dataset is publicly available and ready to use! 📖 #ScienceSky #scRNAseq #SingleCell

Show Post

New preprint! Antibodies activate an immune response… so why do immune cells have an inhibitory receptor FcγRIIB that binds antibodies? We found that FcγRIIB sets a time-limit for signaling. This makes macrophages eventually quit phagocytosis and prevents inflammation. doi.org/10.64898/202...

Show Post

Just published: "Up 4862, Down 57. Spot the bug". Check it out and subscribe to get everything I'm making. #bioinformatics divingintogeneticsandgenomics.kit.com/posts/up-48...

Show Post