Second, we have a more detailed consider a broader range of explanations for the low dCp values of unfolding - including elongated folds in helical bundles and residual structure in the unfolded state. The effect is reduced, but the conclusion remains: The cores of desgned proteins are different!

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How does the extreme thermostability of de novo designed proteins arise? We aimed to answer this question by combined chemical and thermal denaturation of de novo designed minibinders in a paper out now in Protein Science (@proteinsociety.bsky.social): dx.doi.org/10.1002/pro....

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www.sickkids.ca/en/news/arch...

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📢 We're recruiting! A 2-year postdoctoral fellowship is available in our lab at Umeå University! Please share with interested colleagues! 🔗 umustipendie.varbi.com/en/what:job/... 📅 Application deadline: 31 October 2026 #Postdoc #Mitochondria #Proteostasis #AcademicJobs #LifeScience

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Assigning the backbone of a disordered protein is often weeks of work before the biology can even start. I’m sure I’m not alone in having spent long days staring at a stack of spectra, wishing for a just a little more resolution. We built SpinForecast to help!

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