sarahrauscher.bsky.social
Associate Professor, Computational biophysicist @UofT http://rauscher-group.physics.utoronto.ca
👤 Joined on 10 December 2024
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@sarahrauscher.bsky.socialWhen you feel sad, remember that tiny proteins called kinesins are working inside you 24/7 just to keep you alive. Be kind to yourself, your body is doing everything it can to keep you alive. [🎞️ thequantara] Original post
Show Post👍Great news from the @sarahrauscher.bsky.social lab! 🎉
Show PostOur mission is to make intrinsically disordered proteins (IDPs) druggable for everyone. Our first tool, SpinForecast, developed by @bindresearch.org with @ucl.ac.uk, takes a step towards that goal by dramatically speeding up #NMR assignments for IDPs. 🍝🧲🖥️
Show PostNew publication with Chantal Prévost and @sacquin-mo.eurosky.social is out in JPCB ! We show with all-atom MD simulations that disordered alpha-tubulin C-terminal tails wrap around the proline-rich region of the Tau protein, but not so much around its repeat domains pubs.acs.org/doi/10.1021/...
Show PostNew preprint! Do all kinase domains have similar activation mechanisms? We steer AlphaFold2 using "transfer seeding" of known kinases to sample 8.3 ms of MD simulations via Folding@home. We find unique pathways that are kinase-specific and depend on different elements! Link: doi.org/10.64898/202...
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