guertin.bsky.social
Professor of Molecular Biology and Genomics at UConn Health. The lab studies gene regulation, focusing on transcription factors
👤 Joined on 10 August 2023
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@guertin.bsky.social"We should have a longer discussion during the coffee break." Translation: "Your question makes no sense to me at all. I doubt the premise has any basis in reality but I'm worried I will look rude if I trash you in front of 300 people."
Show Post1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348
Show PostGencode and ensembl gtfs aren't available yet for hs1 (as far as I know), which is my biggest hesitancy. I have a lot of code and infrastructure built around both of these.
Show Post⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
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