Online Now: Molecular mechanism of residue-specific nucleosome acetylation Online now:

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I'll cherish our discussions on this during our Sunday evening walks in Heidelberg, congratulations!

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🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

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How can histone acetyl-transferase acetylate a specific histone tail residue ? Using cryo-EM, we captured the MSL complex in a stable post-catalytic state, visualising the acetyl group on H4K16, a central mark for gene regulation authors.elsevier.com/sd/article/S...

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Contributing to this exciting piece of work from the @graeffjohannes.bsky.social lab was a fun ride. We show that partial reprogramming restricted to engram neurons suffices to counteract behavioural, molecular and cellular signs of aging and Alzheimer's. Check it out: www.cell.com/neuron/fullt...

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