BindCraft2 v1.0.4 has been released: with significantly improved VHH, scFv, ARP, and induced fit targeting. WE also improved speed and code stability. Try your difficult campaigns again. Great work by @erikmaeots.bsky.social , Leonardo Tredese and @liza-ch.bsky.social

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IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

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Wait, wait, what !!!!! Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants 686 protein-coding transcripts that mediate cross-locus chromatin interactions in Arabidopsis www.science.org/doi/10.1126/...

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Using AI to write for you - start to finish - is really just you robbing yourself of one of life’s greatest joys: to think through a problem and figure out what you think about it, and in the process becoming passionate enough to take on the new challenge of solving it.

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What’s inside the black box of cis-regulatory control? Our new review proposes a conceptual framework for understanding how regulatory inputs are integrated, linking molecular mechanisms to sequence constraints and quantitative rules, across scales.

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