Reverse transcribed ssDNA derepresses translation of a retron antiviral protein: Molecular Cell

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Heads up! The Symposium on the Immune System of Bacteria 2027 is now open for registrations! 20-22nd July 2027, Churchill College, University of Cambridge, UK Places are limited, so register soon. Visit the website to see our fantastic line-up of speakers: sisb2027.info #phage

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I started my career with P. putida in 1987 trying to purify the XylS regulator of the TOL system in a soluble/active form—to no avail. No one has succeeded thus far despite countless efforts all around the world. It would be awesome to finish my career with a soluble/active XylS & complete the cycle

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Our paper on type II Panoptes is now published at PLOS Biology with new data on phage escapers - quite a step up in microbiology for our lab, led by Sabine Gruschow. Thanks to @erc.europa.eu for funding dx.plos.org/10.1371/jour...

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#Phages can evade #bacterial #immunity by disrupting #antiviral signals like cA3, triggering the Panoptes defense systems. @mfwhite2.bsky.social &co show that Type II Panoptes detects cA3 loss and activates a CARF-TM effector to disrupt membranes & stop infection @plosbiology.org 🧪 buff.ly/1ixwg9v

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