dave dougan
douganlab.bsky.social
Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis #Ndegron https://scholar.google.com/citations?user=6LL-q08AAAAJ&hl=en … views my own
👤 Joined on 16 December 2024
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- 16 Ara 2024, 01:50
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An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease | Science www.science.org/doi/10.1126/...
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ICYMI: New online: A coupled TOM–TIM22 supercomplex in human mitochondrial protein import
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Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease https://www.biorxiv.org/content/10.64898/2026.06.25.734545v1
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How is human mitochondrial ATP synthase assembled from 28 subunits of 17 kinds? Deleting individual subunit/assembly factor, He, Carroll, Walker et al @mrc-mbu.bsky.social show assembly proceeds via constituent structural modules that may have evolved independently link.springer.com/article/10.1...
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Insane. This could happen to any of us and in fact, it already has. Scientists need to stand together more visibly and raise their voices collectively. It cannot become normal that entire labs are shut down and scientific work is undermined.
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