Kresten Lindorff-Larsen

lindorfflarsen.bsky.social

22 March 2026 12:28

When we describe conformational properties of intrinsically disordered proteins we often talk about residual structure, but residual relative to what? There are several approaches to quantify this in conformational ensembles, with one simple being to compare to a reference excluded volume ensemble

Kresten Lindorff-Larsen

lindorfflarsen.bsky.social

18 March 2026 21:03

Proud and honoured to receive the Novo Nordisk Foundation’s Prize for Natural Science Teachers together with Birthe Kragelund and Karen Skriver Teaching takes a village, and I owe many many thanks to amazing colleagues, students, and collaborators over the years science.ku.dk/english/pres...

Martin Steinegger 🇺🇦

martinsteinegger.bsky.social

17 March 2026 12:26

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk

Mohammed AlQuraishi

moalquraishi.bsky.social

13 March 2026 19:25

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Kresten Lindorff-Larsen

lindorfflarsen.bsky.social

08 March 2026 19:40

New paper from former PhD student @tkschulze.bsky.social on supervised learning of protein variant effects across large-scale mutagenesis datasets MAVE/DMS experiments provide large amounts of data for benchmarking variant effect predictors, but may be difficult to use in supervised learning. 1/5