pliotasgroup.bsky.social
Mechanosensitive channels & Membrane Proteins - Structural EPR Spectroscopy at The University of Manchester - DEER/PELDOR/PDS pliotasgroup.org
👤 Joined on 23 January 2025
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@pliotasgroup.bsky.socialJust published: copper(II) binding to Human Serum Albumin. 1st structure including the ATCUN site that is square planar as expected. There are multiple copper(II) sites and EPR (including hyperfine and pulse dipolar) reveals occupation of multiple sites at low loading. doi.org/10.1039/D6QI...
Show PostNew pulse EPR study on the human membrane channel TRAAK enabled through heterologous spin labelling
Show PostWork just published in @natcomms.nature.com rdcu.be/e9ieD demonstrating how pulse dipolar EPR can resolve different states of a human transporter in native membranes. EPR contributions by @ackermannkatrin.bsky.social @st-andrewschem.bsky.social
Show PostProtein–polymer conjugates: how do we understand their structure & dynamics? 🔬Our new review highlights EPR spectroscopy+complementary techniques for insights in vitro & in cells. Read more 👇 www.sciencedirect.com/science/arti... #ProteinPolymerConjugates #EPR #Biomaterials #PolymerScience
Show PostIn our study in @natcomms.nature.com we used #EPR #DEER #PELDOR spectroscopy with single subunit heterologous spin labelling and monitored the entire cap conformational ensemble of the human mechanosensitive TRAAK channel and showed it adopts two states in membranes. www.nature.com/articles/s41...
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