Really enjoyed this commentary, which creates a super framework for current thoughts and future studies on enhancer function.

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Currently reading it, this is brilliant 👌

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🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

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Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

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Happy to share that our previous preprint showing that KMT2B controls the enhancer-like activity of LINE-1 elements is now published in @natcomms.nature.com 🎉 Thanks to all co-authors and to @ibbtec.bsky.social @csic.es @univcantabria.bsky.social www.nature.com/articles/s41...

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