IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

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New commentary from the lab - can we identify principles of transcriptional regulation & cis-regulatory element (CRE) control of gene expression? With @jcornwallscoones.bsky.social & @joadelas.bsky.social in @cp-molcell.bsky.social A thread 🧵 doi.org/10.1016/j.mo...

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MYC targeted de novo binders impair tumor growth https://www.biorxiv.org/content/10.64898/2026.10.15.758618v1

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Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...

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Systematic mapping of enhancers, silencers, and topological elements using prime editing deletion screens www.biorxiv.org/content/10.6... Check out our preprint on next-generation tech for mapping distal regulatory effects! We’re excited to help set this up - please get in touch Thread 👇

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