Claus Wilke

clauswilke.com

12 March 2026 20:52

New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...

Claudèle Lemay-St-Denis

claudele.bsky.social

05 February 2026 20:10

How does catalysis emerge from non-catalytic domains? In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead. A striking case of catalysis evolving from binding.

christofseiler.bsky.social

05 February 2026 20:09

Save the date: April 9 from 4pm to 6pm CET. Our department is hosting an online seminar with @noeliaferruz.bsky.social @sdomcke.bsky.social @const-ae.bsky.social who will talk about models for protein design, large-scale perturbation screens, and benchmarking of perturbation prediction models.

Kevin K. Yang 楊凱筌

kevinkaichuang.bsky.social

05 February 2026 20:08

Excellent review on using generative models to design enzymes @noeliaferruz.bsky.social @lassemiddendorf.bsky.social arxiv.org/abs/2602.03779

Kevin K. Yang 楊凱筌

kevinkaichuang.bsky.social

10 November 2025 15:16

Design stable, folded proteins using only the 10 "ancient" amino acids. www.biorxiv.org/content/10.1...