benjaminfozzy.bsky.social
Protein Biochemist at the University of Manchester researching #ubiquitin #ubl #PTMs in genome stability GoodGymer | Runner | Dog owner
👤 Joined on 21 November 2024
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@benjaminfozzy.bsky.socialCheck out our latest, just out in @MolecularCell! We reveal how common, typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive tumour-specific responses to PARP inhibitors - We propose that a similar synergy may contribute to A-T pathogenesis.
Show PostExcited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
Show PostProfiling the proteome-wide selectivity of diverse electrophiles #nature #MassSpecRSS
Show PostHappy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...
Show PostNominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8
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