katiepickup.bsky.social
🧬 Reviews Editor @biologists.bsky.social 👩🏻🔬 PhD epigenetics & differentiation @uoe-igc.bsky.social Views my own | she/her
👤 Joined on 05 December 2024
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@katiepickup.bsky.socialSometimes, the only way to build back up is to let everything fall apart. This is certainly true at the cellular level. https://www.quantamagazine.org/break-it-to-make-it-how-fracturing-sculpts-tissues-and-organs-20260227/
Show PostHappy to share my PhD work on the regulatory mechanism of E3 ligase RNF213! RNF213 is not a monomer, but a dimer that switches between inhibited and activated states in an ATP-dependent manner. We tracked the activation mechanism and showed how disease mutations can destabilize the inhibited state.
Show Postcould not be prouder of lillie and the fantastic story she uncovered - from a giant E3 ligase with an unexpected dimer switch to moyamoya mutations that hijack its regulation. a beautiful PhD project, full of surprises and scientific creativity doi.org/10.64898/202... - bsky.app/profile/lill...
Show PostRead this thread & weep In our bioethics classes, we’re all going to be teaching our students about this grotesque RFK Jr-funded trial for decades to come White Danes flying in to Guinea-Bissau to withhold a proven intervention—the new Tuskegee And it’s happening in the year of our Lord 2026 🤯
Show PostMost animal species pack sperm DNA with protamines instead of histones. Protamines are essential for male fertility. They are among the fastest-evolving genes in animals. That makes little sense. We think we know why, in a new paper led by @ching-hochang.bsky.social. www.science.org/doi/10.1126/...
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