Nick Polizzi

nickpolizzi.bsky.social

26 June 2026 01:19

Our lab's paper on the de novo design of small-molecule binding proteins is out! In it, we show how neural nets can be trained and used to design binders to drugs with very high success rates. www.nature.com/articles/s41...

Nick Polizzi

nickpolizzi.bsky.social

12 March 2026 01:55

Our paper with @sokrypton.org using AlphaFold2 to predict small-molecule binding sites in proteins is now out in Nature Methods! 🧵 rdcu.be/e7SnX www.nature.com/articles/s41...

shaharbrr.bsky.social

shaharbrr.bsky.social

06 February 2026 18:01

New preprint out! www.biorxiv.org/content/10.6... One of the most salient lessons I learned in all my adventures with screening and protein engineering is the importance of context. The context in which you test a gene or protein determines what function it has.

Dana-Farber News

danafarbernews.bsky.social

31 January 2026 04:57

Congrats to @danafarbernews.bsky.social’s Nicholas Polizzi, PhD, and Edward Boyden, PhD, of @mit.edu @hhmi-science.bsky.social who received a $1.3 million medical research grant from the W. M. Keck Foundation to fund single-molecule in situ protein sequencing via expansion microscopy. bit.ly/4sRPFHY

Ed Boyden

eboyden3.bsky.social

14 July 2025 19:53

Just posted, by Nina Khera, @clairebookworm.bsky.social, and myself: “Involuntary collaboration: a strategy for decentralized science”! Discussing the "invent-deploy-discover-design" model, and why the Bell Labs of the 21st century might be the whole earth. engineeringx.substack.com/p/involuntar...