Glycan recognition by a plant damage-sensing immune receptor | Science share.google/P0cZic4GXOl1...

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Excited to share our latest work! 🍅 Two evolutionarily distinct immune receptors recognize the same viral target, yet differ in their recognition spectra. A fascinating example of convergent evolution in plant immunity!

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Does recognition lead to assembly? The four movement proteins recognized by HREZ—from TMV, ToBRFV, ToMV and PMMoV—also promoted formation of the large HREZ complex. For HREZ, recognition and immune complex assembly were tightly linked. (7/9)

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But the two receptors are not interchangeable. Across movement proteins from eight related viruses, their recognition profiles overlapped but differed. Tm-2² recognized more of the panel, while HREZ strongly recognized the pandemic virus, ToBRFV. (6/9)

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Then came the evolutionary surprise. HREZ and Tm-2² are not close relatives. They sit in distinct branches of the plant NLR immune receptor family. Yet both recognize tobamovirus movement proteins. Two evolutionary paths, one viral target. (5/9)

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