chrysothemisbrown.bsky.social
Pediatrician | Immunologist @MSK Cancer Center | Freeman Hrabowski Scholar, HHMI www.thebrownlaboratory.com
👤 Joined on 13 November 2024
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@chrysothemisbrown.bsky.socialMatching T cells to their cognate peptides presented on MHC molecules from sequence data is a key unsolved problem in computational immunology. A transformative collaboration with @quaidmorris.bsky.social. Led by Olga Lyudovyk, @levinejon.bsky.social & Melissa Pathil! 👇 @mskcancercenter.bsky.social
Show PostCan we predict which T cells recognize which peptides? A lot of the signal is hiding in AlphaFold3's (AF3's) hallucinations. enFoldX: instead of one predicted structure, we use the whole noisy ensemble to predict TCR:pMHC binding. www.biorxiv.org/content/10.6... 💻 🧬 github.com/jonlevi/enFoldX
Show PostIncredible day at #AAI2026 today with brilliant talks and warmth of seeing old and new friends. First, smashing talks by @petterbrodin.bsky.social and @chrysothemisbrown.bsky.social this morning in #EarlylifeImm major symposia. Great discussions and wonderful data
Show PostCongrats to #FreemanHrabowski Scholar Corina Amor Vegas & #HannaGray Fellow Marissa Scavuzzo, both among this year's MIND Prize winners! Recognizing early-to-mid-career scientists, the award honors those with innovative ideas that advance neurodegeneration research: bit.ly/46VrlMh.
Show PostCouldn’t be more proud of my postdoc Manu for securing his own funding—way to go, Manu! ⭐️
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