cddpress.bsky.social

21 October 2026 13:44

“Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer” This work suggests that the combination of #HormonalTherapy and GS inhibitors may overcome therapeutic #Resistance ⤵️ www.nature.com/articles/s41...

cddpress.bsky.social

13 October 2026 08:56

“Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells” DDT pathway components as exploitable vulnerabilities of #TNBC cells ⤵️ nature.com/articles/s41...

cddpress.bsky.social

12 October 2026 15:35

“p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances” Translating these findings to the clinic could potentially benefit the oncological outcome ⤵️ nature.com/articles/s41...

cddpress.bsky.social

09 October 2026 09:51

“JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines” A pharmacologically distinct inhibitor of ribosome biogenesis with broader, dose-dependent chromatin-disruptive activity ⤵️ nature.com/articles/s41...

cddpress.bsky.social

07 October 2026 11:34

“Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress” Read more about the regulatory and functional relationships between oncofetal CS and #ERStress in #Osteosarcoma ⤵️ nature.com/articles/s41...