MolinariLab-ER
molinarilab-er.bsky.social
Endoplasmic reticulum; protein folding and quality control; ERAD and ERLAD for proteasomal and lysosomal protein degradation from the ER; ER-phagy, Recov-ER-phagy and ONM-phagy; organelle fragmentation; IDRs; HaloTag; … My opinions
👤 Joined on 05 December 2024
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- 05 Ara 2024, 09:13
🎉 Bluesky'e katıldı - İlk kullanıcı adı:
@molinarilab-er.bsky.social
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A prework walk in #PapworthWood is quite the luxury. Have a good day everyone and, if possible, find a quiet moment to enjoy.
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Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
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💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation. bit.ly/4fLWe99
Show PostDay 7 Ireland: Tralee Very enjoyable dinner at the Oyster Tavern Oysters + a Guinness Hot seafood platter + Chardonnay The mash potatoes were outstanding (data not shown) Simply no room for pudding though the dessert menu looked great 😁
Show PostSelective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL
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