kranzuschlab.bsky.social
Harvard Medical School, Dana Farber Cancer Institute https://kranzuschlab.med.harvard.edu
👤 Joined on 15 July 2025
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@kranzuschlab.bsky.social🔥Preprint alert!🔥 RNase E-dependent guide generation and activation of the SPARMA defense system Read the thread by Theo on how the short pAgo system SPARMA works, how pAgo guide RNAs are generated, and how pAgo autoimmunity is prevented. Preprint here: www.researchsquare.com/article/rs-1...
Show PostExcited to share this work from our group, together with the Jackson and Beisel labs! 🧬 We found that aminoacylated tRNA fragments can act as signals to activate bacterial immunity, boosting protection by Cas12a3. Very cool biology, and a great collaboration! www.biorxiv.org/content/10.6...
Show PostAnd yet again, the Koonin-Krupovic team awe and amaze us with a review of virus origins…! Which, I will add, is nicely timed for inclusion in an update of a certain Book. @mkrupovic.bsky.social
Show PostVery nice discovery from the Jackson, Bravo and Basel labs. Cleaved tRNA ends, loaded with an amino acid, activate a form of bacterial immunity
Show Post🌱 How do plants read chitin length? The receptor CHIP13 works like a molecular measuring tape. What began 13 years ago with a recalcitrant protein is now in @science.org. Thanks to all my co-authors and colleagues! doi.org/10.1126/scie...
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