omarammar.bsky.social
C. Embryologist | TEDx speaker | #ESHREjc editor & @theESHRE5 | Alum @CheveningFCDO, @Dundeeuni, @UniofOxford | Views own
👤 Joined on 28 October 2023
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@omarammar.bsky.socialI believe Hans Evers said it beautifully: the goal should be "One healthy child at a time with the lowest risk to mother and child" to which I would add "as cost efficiently as possible" #ESHREjc
Show PostRelaxin seems to be the most interesting as it behaves almost like a “system-wide remodeling signal” rather than a narrowly targeted reproductive hormone.#ESHREjc
Show PostReal clinical issue #ESHREjc: women without cycles need AC. But with HDP risk 2–3× higher in oocyte donation, should we be routinely using FMF first-trimester screening + prophylactic aspirin (150 mg, per Nicolaides ASPRE trial) in all AC-FET recipients? www.ajog.org/article/S000...
Show Post#ESHREjc First-trimester serum biomarkers — the best current tool: 📍 PlGF ↓ + sFlt-1 ↑ → angiogenic imbalance (standard T1 PE screen, but less sensitive for late-onset PE) 📍 PAPP-A ↓ → trophoblast dysfunction marker 📍 Combining PlGF + MAP + UtA Doppler detects ~75% of preterm PE at 10–14 weeks.
Show PostYes, testing early but how much early? Interesting evidence from supraphysiologic estradiol levels in fresh ET having only a marginal effect on placental vascularity… awaiting for 1st trimester then (placentation after implantation) www.fertstert.org/article/S001... #eshrejc
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