Vijay Ramani

vram142.bsky.social

06 July 2026 05:40

In short, we discover that chromatin in close spatial proximity share nucleosome spacing patterns in the nucleus. Discovery was made possible via latest in "SAMOSA suite": Ligation Analysis of Single-molecule Sequence Interactions, or LASSI. SAMOSA + 3C = LASSI (we couldn't help ourselves 😆) (2/n)

Vijay Ramani

vram142.bsky.social

06 July 2026 05:39

JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)

Karolin Luger

nucleosomepolice.bsky.social

06 July 2026 05:39

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

Svetlana Dodonova

dodonova-sveta.bsky.social

06 July 2026 05:35

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Karolin Luger

nucleosomepolice.bsky.social

06 July 2026 05:33

New PARP1 preprintfrom the lab, by Alex Fiorenza and our amazing undergrad Mahika Anand. PARP1 functions in DNA repair, but what about its second gig as a chromatin architectural protein? How does it stay enzymatically quiet? Read all about it here. www.biorxiv.org/content/10.6...