Paul Rainey
paulbrainey.bsky.social
Evolutionary geneticist working with microbes. Absorbed by the curiosity of science and ideas. Department of Microbial Population Biology, MPI for Evolutionary Biology, Plön, Germany & ESPCI, Paris, France.
👤 Joined on 21 February 2025
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- 21 Şub 2025, 07:46
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12/ Unlike snowflake yeast, where one mutation hands you collective reproduction, here selection on collectives builds heredity. A slick model for how genes became chromosomes and endosymbionts became organelles. @charly-evos.bsky.social @paulbrainey.bsky.social doi.org/10.64898/2026.08.05.743067
Show Post11/ The mechanism is beautiful. Red and green fused with the yeast's native 2µ plasmid into a single replicon, and both lines independently knocked out FLP1, the recombinase that would otherwise cut the chimera back apart. Restore Flp1 and heredity collapses.
Show Post9/ This next one is super cool. How do unrelated replicators fuse into one heritable unit? Hernandez-Beltran, McConnell, Rogers & Rainey built one from scratch: red and green plasmids in yeast, with selection for yellow cells carrying both.
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"You ever notice everything is stupid until our generation adopts it?" From the latest Private Eye, out now.
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New email to Director Bhattacharya about the unethical hepatitis B study. 1/3
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