"Because manuscripts reflected real progress towards our field’s goals, our assessment systems began relying on them as primary metrics...which is obviously flawed...Generative AI has broken this already-flawed proxy completely" journals.plos.org/plosbiology/...

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Delighted to share this new article where we propose our view for the next generation of human genetics. We argue a need for "Trait Causal Models" linking genetics to effects at all levels of biological structures, and talk about how to get there using gwas, perturbations and observational omics

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This is a truly startling paper. It shows that mRNA can perform regulatory functions *in addition to* its role in encoding a protein. In other words, the distinction between protein-coding RNA and noncoding regulatory RNA is fuzzy. /1 www.science.org/doi/10.1126/...

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New commentary from the lab - can we identify principles of transcriptional regulation & cis-regulatory element (CRE) control of gene expression? With @jcornwallscoones.bsky.social & @joadelas.bsky.social in @cp-molcell.bsky.social A thread 🧵 doi.org/10.1016/j.mo...

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Wayne Mondok (Canadian, born 1961) Yellow Light

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