Kusterlab

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• Stephan Hacker@stephanhacker2.bsky.social21.11.2025 15:37

  A tour-de-force study by the group of Bernhard Küster (@kusterlab.bsky.social). They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics to identify 5,318 confident kinase::substrate relationships for 96 human #kinases www.biorxiv.org/content/10.1... #ChemSky #ChemBio

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• Pedro Beltrao@pedrobeltrao.bsky.social20.11.2025 12:59

  This looks like a fantastic resource to study human kinase signalling. So much MS instrument time.

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• Florian P Bayer@flobayer.bsky.social20.11.2025 11:57

  Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so! We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome. Read more:

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• Tom Lau@tomlau.bsky.social19.11.2025 05:46

  I love lamp

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• Ludwig Lautenbacher@llautenbacher.bsky.social11.11.2025 20:11

  Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...

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