Stephan Hacker

stephanhacker2.bsky.social

21 November 2025 15:37

A tour-de-force study by the group of Bernhard Küster (@kusterlab.bsky.social). They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics to identify 5,318 confident kinase::substrate relationships for 96 human #kinases www.biorxiv.org/content/10.1... #ChemSky #ChemBio

Pedro Beltrao

pedrobeltrao.bsky.social

20 November 2025 12:59

This looks like a fantastic resource to study human kinase signalling. So much MS instrument time.

Florian P Bayer

flobayer.bsky.social

20 November 2025 11:57

Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so! We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome. Read more:

Tom Lau

tomlau.bsky.social

19 November 2025 05:46

I love lamp

Ludwig Lautenbacher

llautenbacher.bsky.social

11 November 2025 20:11

Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...