Jesse Engreitz

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• Jeff Spence@jeffspence.github.io18/10/2026 00:14

  It's been 30 years (!!!) since the conceptualization of GWAS. GWAS has driven tons of discoveries, but with recent experimental developments (CRISPR, single-cell omics), we thought it was time to think about how to drive the next 30 years of human genetics. doi.org/10.5281/zeno...

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• Shawn Cai@xshawncai.bsky.social09/10/2026 17:48

  Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...

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• Sasha Gusev@sashagusevposts.bsky.social29/09/2026 05:08

  Claude made me an app to keep track of exploratory tasks on agentic projects (which quickly get out of control in the session). Point an agent at the workspace/prompt and it will populate tasks as it goes. Everything is recorded in markdowns/csvs. Code: github.com/sashagusev/f...

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• Impact of Genomic Variation on Function@igvfconsortium.bsky.social26/08/2026 21:11

  How do genetic variants affect secreted proteins? A new study introduces MultiSTEP, a scalable method for measuring variant effects in coagulation factor IX. The approach assessed >8,500 F9 missense variants and helped reclassify 63.1% of VUSs. pubmed.ncbi.nlm.nih.gov/40514537/

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• Evgeny Kvon@evgenykvon.bsky.social25/08/2026 15:14

  First synthetic mouse enhancers active in defined embryonic tissues! Great collaboration led by @alex-stark.bsky.social lab now at @natgenet.nature.com

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