Roberto Chica Lab

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• Nick Polizzi@nickpolizzi.bsky.social07/10/2026 18:21

  Great to have NIH support to learn the rules of small-molecule driven allostery in proteins! Plan is to build some pretty useful proteins along the way for biology and medicine. Interested? Reach out! And congrats to my colleague Xin! Clearly DFCI is a great place to tackle bold ideas!

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• Robert E. Campbell@campbell-lab.bsky.social28/08/2026 22:12

  Protein Engineering: Status Report, marks the 40th anniversary of Protein Engineering, Design and Selection and provides a landmark overview of the field. Read the open access article now: academic.oup.com/peds/pages/4...

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• Nick Polizzi@nickpolizzi.bsky.social05/08/2026 00:22

  We can design "static" binders routinely now, but design of "dynamic" shape-changing proteins has remained quite hard. Jeffrey Chang and I asked: why can't we couple small-molecule binding to shape change? After all, natural proteins do it every day. In a new preprint, we show how it can be done. 🧵

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• birtehoecker.bsky.social@birtehoecker.bsky.social15/06/2026 19:30

  rdcu.be/fopFE

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• birtehoecker.bsky.social@birtehoecker.bsky.social15/06/2026 19:30

  Today out in Nature Chemical Biology @springernature.com. Thanks for great collaboration @chicalab.bsky.social

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