SP@RTE

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• SP@RTE@spartelab.bsky.social12/02/2026 11:05

  We are thrilled to share our latest publication in Cell Reports (Cell Press)! A huge thank you to everyone involved in this work! 📖 Read the full paper here: www.cell.com/cell-reports...

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• SP@RTE@spartelab.bsky.social12/02/2026 11:05

  In this study, we reveal that OGG1’s association with DNA during lesion searching involves local DNA distortion, promoting base unstacking. This process is tightly regulated by conserved amino acids encircling the double helix, ensuring stable binding without compromising rapid scanning.

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• Maximilien Martinez@maximil1.bsky.social12/02/2026 10:21

  I am happy to share our latest publication. In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.

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• Cell Reports@cp-cellreports.bsky.social07/02/2026 18:16

  A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

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• Marcin J. Suskiewicz@msuskiewicz.eurosky.social17/11/2025 15:20

  Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

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