Radoslaw (Radek) Szmyd
@szmyd-radoslaw.bsky.social did:plc:om3nitntrh647dvvbkvbdcyv
DSB repair and DDR centred scientist 🧬 Based in Sydney 🇦🇺 CrossFit/fitness 🏋🏻 Food 🍱 and traveling 🌏 enthusiast
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Radoslaw (Radek) Szmyd (@szmyd-radoslaw.bsky.social) ist seit 27 November 2024 auf Bluesky. Das Konto hat 119 Follower, folgt 217 Konten und hat 33 Posts veröffentlicht.
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🧬 Excited to share our new paper, out today in Nature Cell Biology! 📄 www.nature.com/articles/s41... This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵
Post anzeigenThis mobility helps HR, not NHEJ. Microtubule-driven random 3D search works together with RAD54L-driven active search during homology search. Removing vimentin or plectin rescues fluctuations, mobility AND repair in cells without acetylated tubulin. 🤓
Post anzeigenPleased to share a new preprint from the Tijsterman lab that we had the pleasure of collaborating on! How does Polθ engage RPA-coated DNA ends? Read the preprint: www.biorxiv.org/content/10.6... Also check out complementary work from the Walter lab: www.biorxiv.org/content/10.6...
Post anzeigenExcited for lab members @oweneby.bsky.social and @felixsteinruecke.bsky.social for contributing the beautiful cryo-EM structure of the Pol θ-RPA-ssDNA complex to this beautiful story by @joeloparo.bsky.social's and Johannes Walter's labs. Congrats! www.biorxiv.org/content/10.6...
Post anzeigenFor more on telomere maintenance by alternative lengthening of telomeres (ALT) across the cell cycle, check out our recently published review @cp-molcell.bsky.social: www.cell.com/molecular-ce... #Research #Telomeres #ALT #CellCycle #OpenAccess
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