Alex Holehouse
@alexholehouse.bsky.social did:plc:jikts6gfe2anv25vlc5mxoqx
Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him. https://www.holehouselab.com/
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Alex Holehouse (@alexholehouse.bsky.social) ist seit 23 August 2023 auf Bluesky. Das Konto hat 3.159 Follower, folgt 1.251 Konten und hat 299 Posts veröffentlicht.
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We hope you're ready to crack the transcription factor code! Talks from @successprocess.bsky.social and Nicole DelRosso exploring the molecular basis of TF IDR function! TOMORROW (11/5) at noon Central. Sign up here, as always! idpseminars.com
Post anzeigenThank you to my postdoc mentors Tim and Liam, our collaborators Alex and Ryan, and the students who worked on the project Nongyun Wang, Devi Chirumamilla, and Rashmi Mohotti. Preprint here: www.biorxiv.org/content/10.6...
Post anzeigenWhile screening for motifs, we discovered that locally scrambled IDRs were functional, and found conformational dynamics rather than linear sequence predicted function. We then used IDR dynamics as a design target and generated functional IDRs de novo.
Post anzeigenHere, we develop a system to map sequence to function in the IDR of RUNX2, the transcription factor that regulates bone development. We show that specific IDR function is encoded beyond exact amino acid sequence order.
Post anzeigenFolded protein design is now routine, but ~35% of the human proteome lacks stable 3D structure. Synthetic intrinsically disordered regions (IDRs) could be used for cell engineering. However, without structure, the target for biologically functional disordered protein design is not obvious.
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