Yasu Arimura
@yarimura.bsky.social did:plc:4edkf7w3zdzpxskco5ghdrro
Elucidating the structural basis of biological events on chromosomes | chromatin, Xenopus egg extract, cryo-EM | Assistant Professor at Fred Hutch https://research.fredhutch.org/arimura/en.html
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Yasu Arimura (@yarimura.bsky.social) ist seit 12 Februar 2024 auf Bluesky. Das Konto hat 856 Follower, folgt 854 Konten und hat 17 Posts veröffentlicht.
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In short, we discover that chromatin in close spatial proximity share nucleosome spacing patterns in the nucleus. Discovery was made possible via latest in "SAMOSA suite": Ligation Analysis of Single-molecule Sequence Interactions, or LASSI. SAMOSA + 3C = LASSI (we couldn't help ourselves 😆) (2/n)
Post anzeigenJIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Post anzeigenOut today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵
Post anzeigenExcited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
Post anzeigenNew PARP1 preprintfrom the lab, by Alex Fiorenza and our amazing undergrad Mahika Anand. PARP1 functions in DNA repair, but what about its second gig as a chromatin architectural protein? How does it stay enzymatically quiet? Read all about it here. www.biorxiv.org/content/10.6...
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