Ophir Shalem

Ophir Shalem

ophirshalem.bsky.social

Scientist, Associate Professor, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Children’s Hospital of Philadelphia Functional genomics, Proteostasis, Neurodegeneration www.shalemlab.org

👤 Joined on 10 November 2024

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  • 10 Kas 2024, 13:29
    🎉 Bluesky'e katıldı - İlk kullanıcı adı: @ophirshalem.bsky.social

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❤️ Beğendiği Gönderiler

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

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asamelson
29 January 2026 20:13

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇

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Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

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Arc Institute
28 January 2026 19:30

In a new review published in @cp-neuron.bsky.social, @christophthaiss.bsky.social and team synthesize emerging research on intestinal interoception, highlighting how signals from the gut shape communication between the environment, the body, and the brain to maintain human health.

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Complexity at the ribosomal polypeptide tunnel exit. The major N-terminal acetyltransferase NatA may form different complexes on the ribosome to facilitate protein maturation. By Marius Klein & Klemens Wild in Irmgard Sinning's lab BZH & Nina McTiernan in my lab. www.nature.com/articles/s41...

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