This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

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Yeah because the llamas and alpacas make the nanobodies. Camelids I believe and sharks are the only one that make those special variant of antibodies.

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Wonderful Friday for a PhD thesis submission @jaisondsa.bsky.social @wehi-research.bsky.social 🩸Stabilized variants for zero-diagnostics 🦙Nanobodies against Plasmodium adhesins (watch this space) Been incredible working with Jaison across the years and sharing co-supervision with Phillip Pymm

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E. coli is a top cause of UTIs and sepsis—but hard to rapidly detect Seeger lab (U Zurich 🇨🇭) design nanobodies vs the conserved outer membrane protein OmpA that bind >91% of clinical strains Smart linker engineering was able to overcome O-antigen interference to enable the ultra-sensitive capture

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Our lab is attending the UK-ICN (uk-icn.co.uk) AGM this week - look out for out talks! Developing nanobodies as pan-SARS-CoV-2 therapeutics by Luke Jones, today (22/7) at 14:00 High prevalence of sarbecovirus in a single bat roost in Gloucestershire, UK by Dung Nguyen - thursday 24/7 at 9:45

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