Christoffer Merrild
c-merrild.bsky.social
PhD-fellow at Christoffer Clemmensen's laboratory, Novo Nordisk Foundation Center for Basic Metabolic Research. Basic researcher, founder & ecosystem builder
👤 Joined on 07 April 2026
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- 25 Kas 2024, 09:28
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Plasma proteomics showed enrichment of bioenergetic processes. And brain transcriptomics pointed to shared neuronal programs governing energy balance.
Show PostWhen rats were pair-fed and ate the same amount of food, the combo still drove more weight loss. So it's not just appetite suppression, something about energy expenditure is doing work here too. 🔥
Show PostThe idea is "five-receptor polypharmacology." Retatrutide hits three receptors (GLP-1, GIP, glucagon). Cagrilintide adds two more (amylin + calcitonin). Together = five targets in the body's energy-balance system, all hit at once.
Show PostDaily co-administration beat both drugs given alone, AND beat matched-dose combos built on semaglutide or tirzepatide. It also improved cholesterol, triglycerides, and insulin.
Show PostWhat if the next obesity drug isn't one molecule, but several working together? 🧬 New from our lab in #NatureMetabolism: retatrutide + cagrilintide together drove more weight loss than any single drug - or even semaglutide/tirzepatide combos - in obese rats. A thread 👇 #obesitydrugs 🧪
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