Pt with myelofibrosis, NR proteinuria, progressive CKD. Hypercellular glomeruli + intracapillary megakaryocytes, + mesangial sclerosis, +chronic microangiopathic changes c/w MPN-related glomerulopathy. Also renal extramedullary hematopeosis. IHC is CD61 #renalpath #pathsky #nephsky

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We have some wicked PA patients on 200 mg Spiro or more Having an ASI for them would be wonderful - like a medical adrenalectomy (aldosterone only) Otherwise agree Spiro or eplerenone are enough in most HT settings

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So my hypothesis now is that - ASIs are very potent - great in HT & PA like Spiro also - finerenone works in CKM areas as it is a very weak MRA - ergo ASIs will not be great in CKD and possibly also the other HF/CKD trials

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Ignore the setting. If you were to evaluate The Hobbit strictly based on how well the overall set was designed: from cards to mechanics to limited gameplay and constructed relevance...what grade would you give? Our final conclusion: youtu.be/qtZ0wYGOJfA #magicthegathering

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Setback - Novartis and BMS pause their CD19 CAR-T research program (automimmune, not cancer) www.reuters.com/business/hea... 3 deaths from IEC-HPS #rheumsky #Nephsky

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