zhaolabski.bsky.social
We study chromosomal replication & recombinational repair mechanisms, Smc5/6, SUMO-based controls using multidisciplinary approaches. Tweets are a group effort.
👤 Joined on 13 December 2023
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@zhaolabski.bsky.socialIt took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...
Show PostOur latest paper is out in @embojournal.org! Chromatin compaction is a hallmark of apoptosis, but the mechanism & function of this process was unclear. We show apoptotic compaction is required to prevent fragmented DNA from spreading beyond the dying cell, and is driven by histone deacetylation.
Show Post🎉 AlphaBridge Anniversary!! 🎉 Two years ago we released #AlphaBridge as a preprint, and the research community has welcomed and used it since. We are also happy to share that it was recently published in Structure (Cell Press)! Read the paper: www.cell.com/structure/fu...
Show PostVery interesting historical perspective on cohesin and its role in transcriptional regulation: link.springer.com/article/10.1...
Show PostHave you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...
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