michaelglickman.bsky.social
Physician Scientist interested in all things mycobacterial: pathogen, model system, and cancer therapy. Immunology program/ID MSK. Opinions are mine and do not represent those of employer, MSK. Pubs: https://shorturl.at/GaVRW
👤 Joined on 29 October 2023
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@michaelglickman.bsky.socialSome random thoughts: Good science doesn't always need disruptors. Often, it needs load-bearing walls. You can't pivot away from a failed multi-year experiment or "iterate" your way out of a mentee's PhD. Science needs stable foundations, not churn. Don't break the people building on top of it.
Show PostProud and excited to share our first preprint 🚀 in which we • create a high-fitness firewalled organism, • that stably colonizes the mouse gut for >100 days, • resists all tested phages in the gut, • and blocks horizontal gene transfer. + A new method: Chimera genomes to tailor existing synthetic
Show PostI completely agree. "Society must support research in broad fields of inquiry, with a major emphasis on basic science, in order to create the fertile substrate from which tomorrow’s scientific revolutions will arise." journals.asm.org/doi/10.1128/...
Show PostMoreover, we cannot readily predict what science will be revolutionary. Consider the following Nobel prizes, all of them for work done to understand how yeast cells work:
Show PostHappy to share the first preprint out of the Nomburg lab! Many aspects of cellular immunity are shared across the tree of life. Here, we show that some of these conserved aspects of cellular immunity are mirrored by conserved effectors of immune antagonism. Thread below! 1/15
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