pradeepmadapura.bsky.social
Scientist/Professor of Chromatin & Genome Regulation, Blizard Institute, @QMULepigenetics; views are my own. https://www.madapuralab.net/home
👤 Joined on 29 September 2023
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@pradeepmadapura.bsky.socialEach human (resting CD4+ T) cell has about 2 meters of DNA crammed into the nucleus. Therefore, the challenge is not just storing DNA but folding it in a way that preserves function. rdcu.be/fsd7v
Show PostHow can histone acetyl-transferase acetylate a specific histone tail residue ? Using cryo-EM, we captured the MSL complex in a stable post-catalytic state, visualising the acetyl group on H4K16, a central mark for gene regulation authors.elsevier.com/sd/article/S...
Show PostCUT&ID does Genomics+Proteomics in one shot via the fusion protein Lazarus Out @narjournal.bsky.social Unstoppable @annanordin.bsky.social is thinker+executor Get in touch if you wish to try it—plasmid soon @addgene.bsky.social 🙏 @liu.se @scilifelab.se @kawresearch.bsky.social @cancerfonden
Show PostWhat’s next in transcription and chromatin biology? Find out in York, 18–20 November, as researchers come together to share the latest breakthroughs in epigenetics, genome organisation and transcriptional regulation. Book your place. https://www.eventsforce.net/biochemsoc/286/register
Show Post5\ Why does it matter? Failure to disrupt interactions is associated with a stronger transcriptional downregulation of the associated genes, suggesting that not only developmental gain, but also loss of interactions is important for transcriptional activity.
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