Sean Bresnahan

seantbres.bsky.social

31 August 2026 23:52

Our new preprint introduces ✨ICONIC✨: an R package making causal inference accessible for observational omics. It unifies genetic instruments (Mendelian randomization) and negative controls (proximal inference) for mediation analysis under unmeasured confounding. www.medrxiv.org/content/10.6...

Yung-Han (Tina) Chang

ytchang11.bsky.social

20 May 2026 21:24

Congratulations to @taylorhead.bsky.social for her excellent presentation at STATGEN 2026! She is developing methods for isoform-level fine-mapping in TWAS using long-read-informed priors.💻

Sean Bresnahan

seantbres.bsky.social

06 May 2026 19:02

Shout-out to @taylorhead.bsky.social who is presenting prescient work for TWAS studies at #bog26 today! Using long-read RNA-seq to inform isoform-level priors, this work enables Bayesian fine-mapping of causal isoforms by integrating tissue-specific annotation and structural similarity. Poster 108!

Sean Bresnahan

seantbres.bsky.social

27 March 2026 16:16

🧬Another new preprint with @jonhuang.bsky.social @uhmanoa.bsky.social & @arjunbhattac.bsky.social @mdanderson.bsky.social ! We used variation in how PFAS cross the placenta to dissect the transcriptional architecture of effects on birthweight & gestational age🧵 www.biorxiv.org/content/10.6...

Arjun Bhattacharya

arjunbhattac.bsky.social

27 March 2026 16:16

Another preprint from our group @mdanderson.bsky.social led by talented postdoc @seantbres.bsky.social! Joint with @jonhuang.bsky.social, exploring the intersection of environmental toxins, maternal/fetal health, and placental txomics. Tweet thread below!