🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

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🚀 Worldwide Sodium Channel Seminars are back for Season 4! Starts Nov 3 with talk from Samantha Salvage on cardiac Nav: "Targeting the cardiac sodium channel and its alternatively spliced variants with fragment antibodies" Program & link to connect: lnkd.in/e7TRu8Hn #SodiumChannels #IonChannels

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Our AM-3 paper is out in Cell. Opioids are indispensable therapeutics, but have severe side effects. Because they are administered systemically, it is hard to dissect how they work, and to separate side effects. So we built one you can switch on and off with light. 🧵 www.cell.com/cell/abstrac...

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11th October 2021 The wall of Boston Ivy at Churchill College looking spectacular today in the autumn sun five years ago today.

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Ion channels are drugged routinely, but hitting one subtype and sparing close relatives remains difficult. We designed a de novo miniprotein binder against human ASIC1a, a channel that contributes to turning acidosis into neuronal death during stroke. Preprint: www.biorxiv.org/content/10.6... 1/n

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