ozvanbocher.bsky.social
Assitant Professor | Université de Bretagne Occidentale | Statistical Genetics | Multi-omics analyses
👤 Joined on 20 January 2025
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@ozvanbocher.bsky.socialRESEARCH | @ozvanbocher.bsky.social E Zeggini (U Brest, Helmholtz Munich) et al. The causal links of gene expression and protein abundance on type 2 diabetes risk in 4 ancestries 🧪
Show PostOur multi-ancestry, multi-tissue MR study for type 2 diabetes is out in Nature Metabolism! Amazing collab with the Type 2 Diabetes Global Genetics Initiative. We showed that causal effects are mostly shared across ancestries but are highly heterogeneous across tissues. www.nature.com/articles/s42...
Show PostFirst time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....
Show PostBoth genomic control & LDSC intercept correction cause severe power loss in GWAS, not counterbalanced by type I error control. A very much needed + interesting analysis by Archit Singh @ozvanbocher.bsky.social @elezeggini.bsky.social et al onlinelibrary.wiley.com/doi/full/10....
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