Figuring out how cells achieve such a feat requires collaboration between biologists and mathematical modellers who work in tandem to probe and understand the central mechanisms that underly cell navigation. If you're curious to learn more, my preprint is live 👇 www.biorxiv.org/content/10.6...

Show Post

By tweaking simple models of these core circuits, we reverse-engineer the same challenges evolution faced. It shows us how simple primordial machinery paved the way for the highly robust yet flexible microscopic navigators that build our bodies and fight off infections today.

Show Post

From immunity to development, cells must navigate tortuous paths through our tissues. How? I use simulations and mathematical models to probe the mechanisms behind this impressive navigation. See how I explore these mechanochemical circuits and catch my new preprint at the end of this thread!

Show Post

All in all, RhoGAP15B locally suppresses RhoA–Myosin II at the leading edge, creating a relaxed cortical zone that stabilises protrusions while possibly helping to dictate the cycles of contractility/extension, thereby setting the pace for migration.

Show Post

RhoA activity (measured with a FRET sensor) is increased with RhoGAP15B RNAi. While there is normal rear–front asymmetry in migrating border cell clusters, the loss of RhoGAP15B leads to elevated, spatially uniform RhoA activity, consistent with excessive cortical Myosin-driven contractility.

Show Post