moldovanlab.bsky.social
Genome stability, DNA repair, replication stress, functional genomics, basic cancer biology
👤 Joined on 17 December 2024
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@moldovanlab.bsky.socialOur latest publication by @jessel-ap.bsky.social is out in @cp-cellreports.bsky.social. We show that DNA damage in late mitosis triggers an ATM-dependent increase in RNF126 and BRAP, which promote cell survival under these conditions. With help from @rfreirelab.bsky.social doi.org/10.1016/j.ce...
Show Post🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
Show PostHappy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...
Show Postthis week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.
Show Post🥳 Out now @embojournal.org! Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications. p62 is usually linked to #autophagy — but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
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