suyangzhang.bsky.social
Group leader at MRC Laboratory of Molecular Biology #transcription #splicing #cryoEM https://www2.mrc-lmb.cam.ac.uk/groups/zhang/#foogallery-82/i:165
👤 Joined on 28 January 2025
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@suyangzhang.bsky.socialVery proud of this study! Two fundamental processes in gene expression turn out less tightly connected than thought. And their relationship may help explain some surprising vulnerabilities of cancer cells. A big thank you to Agata and Deepshika for years of hard work, and kudos to all collaborators!
Show PostAfter excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)
Show PostHappy to share that, after 17 years abroad, I’m returning to Poland to establish my lab at IIMCB in Warsaw! 🇵🇱 Excited to start this new chapter and looking forward to the adventures ahead!
Show PostWe have 2 new preprints on @biorxivpreprint.bsky.social that describe reconstitution of #Alzheimers paired helical filaments in experimental model systems: one in human brain organoids and one in murine primary cultures. www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
Show PostNew preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...
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