We are excited to share our pan-pangenome paper! This is a long time coming work of my postdoc with the incredible @psudmant.bsky.social, and a stellar group of people! I hope you enjoy reading it! And I am excited to talk more more about it this week at #PEQG26!! www.biorxiv.org/content/10.6...

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Thank you #PEQG26 for the best conference of my life! Had so much fun chairing, connecting with my NYU crew and re-connecting with fabulous past and present Sudmant lab and Berkeley IB folks! What a ride! :)

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1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

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We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...

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To be more explicit, I'm surprised that someone could get better performance beyond what is already an impressively fast mapper*, but if anyone could do it, it'd be you. * from my own testing, I had trouble getting just file reading that was faster than what minimap2 achieved for the full process.

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