Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo. Full SODa-BIC trial results and Research Summary: https://nej.md/4ofXcyq

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With bipartisan support for improving clinical evidence for pregnant & lactating patients growing, a team of @brown.edu researchers writes in a new @statnews.com opinion about their idea for an easy first step to narrow the gaps in #pregnancy data.

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Among adults with endocarditis caused by 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴, 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse. POET II trial results: https://nej.md/3UGyah8 #ESCCongress

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In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months. Full FIND-CKD trial results and Research Summary: https://nej.md/4wWOFV4

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Elevated #LDLCholesterol was associated with 3.6 million deaths worldwide in 2023, and the total burden has risen since 1990 as population growth and aging offset declines in age-standardized cardiovascular rates. ja.ma/4waPCYt

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